Take clonazepam accurately as prescribed. Explain to your healthcare provider in case you feel that clonazepam is not Operating. Call your healthcare supplier immediately or go to the nearest crisis place should you expertise any of the following major signs or symptoms.
Propoxyphene may possibly impair the psychological and/or physical capabilities demanded for your general performance of potentially hazardous responsibilities, for instance driving a car or truck or functioning machinery. The client should be cautioned accordingly.
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Propoxyphene is additionally assumed to possess CYP3A4 and CYP2D6 enzyme inhibiting Houses. Coadministration using a drug That could be a substrate of CYP3A4 or CYP2D6, may possibly end in greater plasma concentrations and amplified pharmacologic or adverse consequences of that drug.
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Propoxyphene undergoes in depth initial-move metabolism by intestinal and hepatic enzymes. The most important route of metabolism is cytochrome CYP3A4 mediated N-demethylation to norpropoxyphene, that is excreted because of the kidneys. Ring hydroxylation and glucuronide development are small metabolic pathways.
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Zidovudine: The pharmacologic results of zidovudine may be reduced due to enhanced nonhepatic or renal clearance of zidovudine.
In combination with using an opioid antagonist, the patient might call for watchful titration by having an anticonvulsant to regulate convulsions. Activated charcoal can adsorb a substantial volume of ingested propoxyphene.
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